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Fachliteratur
Hier finden sie unsere Fachinformationen sowie wissenschaftliche Studien und Anwendungsbeobachtungen zur Mitochondrialen Medizin (MitoMed).
mse-Fachinformationen
- Q10 im Fokus
- Interaktion zwischen Arzneimitteln und Ubiquinon Q10
- Behandlung von Hepatitis B Non- und Lowrespondern mittels LeuMit und einmaliger Impfung mit herkömmlichen rekombinanten Hepatitis B-Impfstoffen
- Arznei-Ergänzungsstoffe (AEGS®)
- Autismus und ADHS
- Diabetes Mellitus
- MitoMedizin bei Herzerkrankungen
- Krebs und Mitochondriale Medizin
- Neurodegenerative Erkrankungen
- Schmerzen
- Darmerkrankungen
- Vitamin A
- Spermidin
- Schlafapnoe
- Perioperative Pflege
- Tinnitus
- Neurodermitis
- COVID-19
- Alpha-ketoglutarat (deutsch)
- Alpha-ketoglutarat (englisch)
- Kaliumcitrat
Wissenschaftliche Studien in Kooperation mit mse Pharmazeutika
- A Pilot Clinical Study of Liquid Ubiquinol Supplementation on Cardiac Function in Pediatric Dilated Cardiomyopathy
Fong-Lin Chen, Po-Sheng Chang, Yi-Chin Lin and Ping-Ting Lin
Nutrients 2018, 10(11), 1697; https://doi.org/10.3390/nu10111697
- Age-Dependent Loss of Mitochondrial Function in Epithelial Tissue Can Be Reversed by Coenzyme Q10
Schniertshauer D, Gebhard D, Bergemann J
Journal of Aging Research
Volume 2018, Article ID 6354680, 8 pages https://doi.org/10.1155/2018/6354680
- Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: a double-blind, randomised, placebo-controlled trial
Chi-Hua Yen, Ying-Ju Chu, Bor-Jen Lee, Yi-Chin Lin and Ping-Ting Lin
British Journal of Nutrition (2018), 120, 57–63; doi:10.1017/S0007114518001241
- Accelerated Regeneration of ATP Level after Irradiation in Human Skin Fibroblasts by Coenzyme Q10
Daniel Schniertshauer, Sonja Müller, Tobias Mayr, Tanja Sonntag, Daniel Gebhard and Jörg Bergemann
Photochemistry and Photobiology, 2016, 92: 488–494; DOI: 10.1111/php.12583
- Short-Term Effects of Coenzyme Q10 in Progressive Supranuclear Palsy: A Randomized, Placebo-Controlled Trial
Maria Stamelou, Alexander Reuss, Ulrich Pilatus, Jörg Magerkurth, Petra Niklowitz, Karla M. Eggert, Andrea Krisp, Thomas Menke, Carmen Schade-Brittinger, Wolfgang H. Oertel and Günter U. Höglinger
Movement Disorders, Vol. 23, No. 7, 2008, pp. 942–949
- Coenzyme Q10 combined with mild hypothermia after cardiac arrest: a preliminary study
Damian MS, Ellenberg D, Gildemeister R, Lauermann J, Simonis G, Sauter W, Georgi C
Circulation 2004, 110(19), 3011-6; https://doi.org/10.1161/01.CIR.0000146894.45533.C2
- QuinoMit Q10-Fluid attenuates hydrogen peroxide-induced irregular beating in mouse pluripotent stem cell-derived cardiomyocytes
Nguemo F, Nembo EN, Kamga Kapchoup MV, Enzmann F, Hescheler J
Biomed Pharmacother 2021; 142:112089; https://doi.org/10.1016/j.biopha.2021.112089
Anwendungsbeobachtungen in Kooperation mit mse Pharmazeutika
- Anwendungsbeobachtung zur Hautpflege bei Neurodermitis
Simone Steffens, Ästhetische Dermatologie 2017
- Ergänzende Gabe von Guttaquinon (flüssiges Q1O) bei entzündlichen Parodontalerkrankungen
Dr. Klaus Erler et al.;
GZM Praxis und Wissenschaft (Fachorgan der Internationalen Gesellschaft für Ganzheitliche Zahn-Medizin e.V.) 2002
Weitere wissenschaftliche Studien zur MitoMed
Die Mitochondriale Medizin (MitoMed) findet in nahezu allen medizinischen Fachgebieten Anwendung. Hier finden Sie zahlreiche wissenschaftliche Studien dazu.
Dermatologie
- Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist.
Barrea L, Savanelli MC, Di Somma C, Napolitano M, Megna M, Colao A, Savastano S.
Rev Endocr Metab Disord. 2017 Jun;18(2):195-205.
doi: 10.1007/s11154-017-9411-6. Review.
- Clinical and biochemical effects of coenzyme Q(10), vitamin E, and selenium supplementation to psoriasis patients.
Kharaeva Z, Gostova E, De Luca C, Raskovic D, Korkina L.
Nutrition. 2009 Mar;25(3):295-302. DOI: 10.1016/j.nut.2008.08.015
- Role of cellular oxidative stress and cytochrome c in the pathogenesis of psoriasis.
Gabr SA, Al-Ghadir AH.
Arch Dermatol Res. 2012 Aug;304(6):451-7. DOI: 10.1007/s00403-012-1230-8
- Oxidative Stress in Atopic Dermatitis.
Ji H, Li XK.
Oxid Med Cell Longev. 2016;2016:2721469. DOI: 10.1155/2016/2721469
- Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome.
Vollmer DL, West VA, Lephart ED.
Int J Mol Sci. 2018 Oct 7;19(10). DOI: 10.3390/ijms19103059
- Targeting the redox balance in inflammatory skin conditions.
Wagener FA, Carels CE, Lundvig DM.
Int J Mol Sci. 2013 Apr 26;14(5):9126-67. DOI: 10.3390/ijms14059126
- Coenzyme q10 ameliorates ultraviolet B irradiation induced cell death through inhibition of mitochondrial intrinsic cell death pathway.
Jing L, Kumari S, Mendelev N, Li PA.
Int J Mol Sci. 2011;12(11):8302-15. DOI: 10.3390/ijms12118302
- Stimulation of skin’s energy metabolism provides multiple benefits for mature human skin.
Blatt T, Lenz H, Koop U, Jaspers S, Weber T, Mummert C, Wittern KP, Stäb F, Wenck H.
Biofactors. 2005;25(1-4):179-85. PMID: 16873944
- Aging skin is functionally anaerobic: importance of coenzyme Q10 for anti aging skin care.
Prahl S, Kueper T, Biernoth T, Wöhrmann Y, Münster A, Fürstenau M, Schmidt M, Schulze C, Wittern KP, Wenck H, Muhr GM, Blatt T.
Biofactors. 2008;32(1-4):245-55. PMID: 19096122
Diabetologie
- Effects of Coenzyme Q10 Supplementation on Serum Values of Gamma-glutamyl transferase, Pseudocholinesterase, Bilirubin, Ferritin, and High-Sensitivity C-Reactive Protein in Women with Type 2 Diabetes.
Gholami M, Rezvanfar MR, Delavar M, Abdollahi M, Khosrowbeygi A.
Exp Clin Endocrinol Diabetes. 2019 May;127(5):311-319. DOI: 10.1055/s-0043-124183
- Effects of Coenzyme Q10 Supplementation on Gene Expressions Related to Insulin, Lipid, and Inflammation Pathways in Patients With Diabetic Nephropathy.
Heidari A, Hamidi G, Soleimani A, Aghadavod E, Asemi Z.
Iran J Kidney Dis. 2018 Jan;12(1):14-21. PMID: 29421772
- Alpha-lipoic acid and coenzyme Q10 combination ameliorates experimental diabetic neuropathy by modulating oxidative stress and apoptosis.
Sadeghiyan Galeshkalami N, Abdollahi M, Najafi R, Baeeri M, Jamshidzade A, Falak R, Davoodzadeh Gholami M, Hassanzadeh G, Mokhtari T, Hassani S, Rahimifard M, Hosseini A.
Life Sci. 2019 Jan 1;216:101-110. DOI: 10.1016/j.lfs.2018.10.055
- Coenzyme Q10 protects against β-cell toxicity induced by pravastatin treatment of hypercholesterolemia.
Lorza-Gil E, de Souza JC, García-Arévalo M, Vettorazzi JF, Marques AC, Salerno AG, Trigo JR, Oliveira HCF.
J Cell Physiol. 2018 Dec 7. DOI: 10.1002/jcp.27932
- Effects of coenzyme Q10 on cardiovascular and metabolic biomarkers in overweight and obese patients with type 2 diabetes mellitus: a pooled analysis.
Huang H, Chi H, Liao D, Zou Y.
Diabetes Metab Syndr Obes. 2018 Nov 29;11:875-886. DOI: 10.2147/DMSO.S184301
Endokrinologie
- Thyroid hormones and antioxidant systems: focus on oxidative stress in cardiovascular and pulmonary diseases.
Mancini A, Raimondo S, Di Segni C, Persano M, Gadotti G, Silvestrini A, Festa R, Tiano L, Pontecorvi A, Meucci E.
Int J Mol Sci. 2013 Dec 9;14(12):23893-909. DOI: 10.3390/ijms141223893
- Hormonal influence on coenzyme Q(10) levels in blood plasma.
Mancini A, Festa R, Raimondo S, Pontecorvi A, Littarru GP.
Int J Mol Sci. 2011;12(12):9216-25. DOI: 10.3390/ijms12129216
- Analyses of antioxidant status and nucleotide alterations in genes encoding antioxidant enzymes in patients with benign and malignant thyroid disorders.
Ramli NSF, Mat Junit S, Leong NK, Razali N, Jayapalan JJ, Abdul Aziz A.
PeerJ. 2017 Jun 1;5:e3365. DOI: 10.7717/peerj.3365
- Coenzyme Q10 evaluation in pituitary-adrenal axis disease: preliminary data.
Mancini A, Bianchi A, Fusco A, Sacco E, Leone E, Tilaro L, Porcelli T, Giampietro A, Principi F, De Marinis L, Littarru GP.
Biofactors. 2005;25(1-4):197-9. PMID: 16873946
Gastroenterologie
- Systematic review: human gut dysbiosis induced by non-antibiotic prescription medications.
Le Bastard Q, Al-Ghalith GA, Grégoire M, Chapelet G, Javaudin F, Dailly E, Batard E, Knights D, Montassier E.
Aliment Pharmacol Ther. 2018 Feb;47(3):332-345. DOI: 10.1111/apt.14451
- The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome.
Traber MG, Buettner GR, Bruno RS.
Redox Biol. 2018 Dec 26; 21: 101091. DOI: 10.1016/j.redox.2018.101091
- Tumor necrosis factor alpha reduces intestinal vitamin C uptake: a role for NF-κB-mediated signaling.
Subramanian VS, Sabui S, Subramenium GA, Marchant JS, Said HM.
Am J Physiol Gastrointest Liver Physiol. 2018 Aug 1;315(2):G241-G248. DOI: 10.1152/ajpgi.00071.2018
- Inhibition of intestinal ascorbic acid uptake by lipopolysaccharide is mediated via transcriptional mechanisms.
Subramanian VS, Sabui S, Moradi H, Marchant JS, Said HM.
Biochim Biophys Acta Biomembr. 2018 Feb;1860(2):556-565. DOI: 10.1016/j.bbamem.2017.10.010
- Peroxynitrite and inflammatory bowel disease.
McCafferty DM.
Gut. 2000 Mar;46(3):436-9. DOI: 10.1136/gut.46.3.436
- Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2.
Hangas A, Aasumets K, Kekäläinen NJ, Paloheinä M, Pohjoismäki JL, Gerhold JM, Goffart S.
Nucleic Acids Res. 2018 Oct 12;46(18):9625-9636. doi: 10.1093/nar/gky793. DOI: 10.1093/nar/gky793
- Is Coenzyme Q10 Effective in Protection against Ulcerative Colitis? An Experimental Study in Rats.
Ewees MG, Messiha BA, Abo-Saif AA, Abd El-Latif HA.
Biol Pharm Bull. 2016;39(7):1159-66. DOI: 10.1248/bpb.b16-00124
- Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research.
Chatzispyrou IA, Held NM, Mouchiroud L, Auwerx J, Houtkooper RH.
Cancer Res. 2015 Nov 1;75(21):4446-9. doi: 10.1158/0008-5472.CAN-15-1626
- Coenzyme Q10 in combination with triple therapy regimens ameliorates oxidative stress and lipid peroxidation in chronic gastritis associated with H. pylori infection.
Rahmani A, Abangah G, Moradkhani A, Hafezi Ahmadi MR, Asadollahi K.
J Clin Pharmacol. 2015 Aug;55(8):842-7. doi: 10.1002/jcph.508
- Depleted mucosal antioxidant defences in inflammatory bowel disease.
Buffinton GD1, Doe WF.
Free Radic Biol Med. 1995 Dec;19(6):911-8. PMID: 8582668
- Altered intestinal microbiota-host mitochondria crosstalk in new onset Crohn’s disease.
Mottawea W, Chiang CK, Mühlbauer M, Starr AE, Butcher J, Abujamel T, Deeke SA, Brandel A, Zhou H, Shokralla S, Hajibabaei M, Singleton R, Benchimol EI, Jobin C, Mack DR, Figeys D, Stintzi A.
Nat Commun. 2016 Nov 23;7:13419. doi: 10.1038/ncomms13419.
Gynäkologie / Andrologie
- Effect of Coenzyme Q10 Supplementation on Testosterone.
Banihani SA.
Biomolecules. 2018 Dec 13;8(4). DOI: 10.3390/biom8040172
- Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial.
Xu Y, Nisenblat V, Lu C, Li R, Qiao J, Zhen X, Wang S.
Reprod Biol Endocrinol. 2018 Mar 27;16(1):29. DOI: 10.1186/s12958-018-0343-0
- Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging.
Ben-Meir A, Burstein E, Borrego-Alvarez A, Chong J, Wong E, Yavorska T, Naranian T, Chi M, Wang Y, Bentov Y, Alexis J, Meriano J, Sung HK, Gasser DL, Moley KH, Hekimi S, Casper RF, Jurisicova A
Aging Cell. 2015 Oct;14(5):887-95. DOI: 10.1111/acel.12368
- CoQ10 Supplementation in Patients Undergoing IVF-ET: The Relationship with Follicular Fluid Content and Oocyte Maturity.
Giannubilo SR, Orlando P, Silvestri S, Cirilli I, Marcheggiani F, Ciavattini A, Tiano L.
Antioxidants (Basel). 2018 Oct 13;7(10). DOI: 10.3390/antiox7100141
- Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia.
Teran E, Hernandez I, Nieto B, Tavara R, Ocampo JE, Calle A.
Int J Gynaecol Obstet. 2009 Apr;105(1):43-5. DOI: 10.1016/j.ijgo.2008.11.033
HNO
- Efficacy of different routes of administration for Coenzyme Q10 formulation in noise-induced hearing loss: systemic versus transtympanic modality.
Fetoni AR, Troiani D, Eramo SL, Rolesi R, Paludetti Troiani G.
Acta Otolaryngol. 2012 Apr;132(4):391-9. DOI: 10.3109/00016489.2011.652307
- Dietary supplementation of coenzyme Q10 plus multivitamins to hamper the ROS mediated cisplatin ototoxicity in humans: A pilot study.
Scasso F, Sprio AE, Canobbio L, Scanarotti C, Manini G, Berta GN, Bassi AM.
Heliyon. 2017 Feb 20;3(2):e00251. DOI: 10.1016/j.heliyon.2017.e00251 Free PMC Article
Immunologie
- Biochemical deficiencies of coenzyme Q10 in HIV-infection and exploratory treatment.
Folkers K, Langsjoen P, Nara Y, Muratsu K, Komorowski J, Richardson PC, Smith TH.
Biochem Biophys Res Commun. 1988 Jun 16;153(2):888-96. DOI: 10.1016/s0006-291x(88)81179-3
- Coenzyme Q10 improves the survival, mesenteric perfusion, organs and vessel functions in septic rats.
Ozer EK, Goktas MT, Kilinc I, Pehlivan S, Bariskaner H, Ugurluoglu C, Iskit AB.
Biomed Pharmacother. 2017 Jul;91:912-919. DOI: 10.1016/j.biopha.2017.05.017
- Coenzyme Q10 and α-lipoic acid: antioxidant and pro-oxidant effects in plasma and peripheral blood lymphocytes of supplemented subjects.
Silvestri S, Orlando P, Armeni T, Padella L, Brugè F, Seddaiu G, Littarru GP, Tiano L.
J Clin Biochem Nutr. 2015 Jul;57(1):21-6. DOI: 10.3164/jcbn.14-130
- Coenzyme Q10 increases T4/T8 ratios of lymphocytes in ordinary subjects and relevance to patients having the AIDS related complex.
Folkers K, Hanioka T, Xia LJ, McRee JT Jr, Langsjoen P.
Biochem Biophys Res Commun. 1991 Apr 30;176(2):786-91. DOI: 10.1016/s0006-291x(05)80254-2
- Coenzyme Q10 Supplementation Modulates NFκB and Nrf2 Pathways in Exercise Training.
Pala R, Orhan C, Tuzcu M, Sahin N, Ali S, Cinar V, Atalay M, Sahin K.
J Sports Sci Med. 2016 Feb 23;15(1):196-203. eCollection 2016 Mar. PMCID: PMC4763840
- Enhancement of antibody production by the addition of Coenzyme-Q(10).
Konno Y, Aoki M, Takagishi M, Sakai N, Koike M, Wakamatsu K, Hosoi S
Cytotechnology. 2011 Mar;63(2):163-70. doi: 10.1007/s10616-010-9330-9
Inflammation
- Antioxidant enzymes, occupational stress and burnout in workers of a prehospitalary emergency service.
Moragón AC, De Lucas García N, Encarnación López Fernández M, Rodriguez-Manzaneque AS, Jimenez Fraile JA.
Eur J Emerg Med. 2005 Jun;12(3):111-5. PMID: 15891442
- Psychosocial work environment and oxidative stress among nurses‘.
Salem EA, Ebrahem SM.
J Occup Health. 2018 Mar 27;60(2):182-191. DOI: 10.1539/joh.17-0186-OA
- Relationship between oxidative and occupational stress and aging in nurses of an intensive care unit.
Casado A, Castellanos A, López-Fernández ME, Ruíz R, Aroca CG, Noriega F.
Age (Dordr). 2008 Dec;30(4):229-36. DOI: 10.1007/s11357-008-9052-5
- Total antioxidant capacity and malondialdehyde in depressive rotational shift workers.
Banoth B, Cassel SL.
J Environ Public Health. 2013;2013:150693. DOI: 10.1155/2013/150693
- Mitochondria in innate immune signaling.
Banoth B, Cassel SL.
Transl Res. 2018 Dec;202:52-68 DOI: 10.1016/j.trsl.2018.07.014
- Mitochondrial DNA in innate immune responses and inflammatory pathology.
West AP, Shadel GS.
Nat Rev Immunol. 2017 Jun;17(6):363-375 DOI: 10.1038/nri.2017.21
- Dietary supplementation with a superoxide dismutase-melon concentrate reduces stress, physical and mental fatigue in healthy people: a randomised, double-blind, placebo-controlled trial.
Carillon J, Notin C, Schmitt K, Simoneau G, Lacan D.
Nutrients. 2014 Jun 19;6(6):2348-59.
- Decreased coenzyme Q10 concentration in plasma of children with cystic fibrosis.
Oudshoorn JH, Lecluse AL, van den Berg R, Vaes WH, van der Laag J, Houwen RH.
J Pediatr Gastroenterol Nutr. 2006 Nov;43(5):646-50. PMID: 17130743
- Effects of an Antioxidant-enriched Multivitamin in Cystic Fibrosis. A Randomized, Controlled, Multicenter Clinical Trial.
Sagel SD, Khan U, Jain R, Graff G, Daines CL, Dunitz JM, Borowitz D, Orenstein DM, Abdulhamid I, Noe J, Clancy JP, Slovis B, Rock MJ, McCoy KS, Strausbaugh S, Livingston FR, Papas KA, Shaffer ML.
Am J Respir Crit Care Med. 2018 Sep 1;198(5):639-647. DOI: 10.1164/rccm.201801-0105OC
- Effects of coenzyme Q10 supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial.
Zarei P, Rezvanfar MR, Ansarihadipour H, Delavar M, Abdollahi M, Khosrowbeygi A.
J Res Med Sci. 2018 Oct 26;23:91. DOI: 10.4103/jrms.JRMS_970_17
- Simultaneous detection of reduced and oxidized forms of coenzyme Q10 in human cerebral spinal fluid as a potential marker of oxidative stress.
Nagase M, Yamamoto Y, Mitsui J, Tsuji S.
J Biochem Nutr. 2018 Nov;63(3):205-210. DOI: 10.3164/jcbn.17-131
- Effect of Coenzyme Q10 on Psychopathological Symptoms in Fibromyalgia Patients.
Alcocer-Gómez E, Culic O, Navarro-Pando JM, Sánchez-Alcázar JA, Bullón P.
CNS Neurosci Ther. 2017 Feb;23(2):188-189. DOI: 10.1111/cns.12668
- Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation.
Miyamae T, Seki M, Naga T, Uchino S, Asazuma H, Yoshida T, Iizuka Y, Kikuchi M, Imagawa T, Natsumeda Y, Yokota S, Yamamoto Y.
Redox Rep. 2013;18(1):12-9. DOI: 10.1179/1351000212Y.0000000036
Kardiologie
- Myocardial energetics and ubiquinol in diastolic heart failure
Angelina Bates MSN, APRN Qiuhua Shen PhD, APRN, RN John B. Hiebert MD Amanda Thimmesch BA Janet D. Pierce PhD,
Nurs Health Sci. 2014 Dec;16(4):428-33. DOI: 10.1111/nhs.12168
- Influence of coenzyme Q(10) and cerivastatin on the flow-mediated vasodilation of the brachial artery: results of the ENDOTACT study.
Kuettner A, Pieper A, Koch J, Enzmann F, Schroeder S.
Int J Cardiol. 2005 Feb 28;98(3):413-9. DOI: 10.1016/j.ijcard.2004.01.004
- Reduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years: Follow-Up Results of a Prospective Randomized Double-Blind Placebo-Controlled Trial in Elderly Citizens.
Alehagen U, Aaseth J, Johansson P.
PLoS One. 2015 Dec 1;10(12):e0141641 DOI: 10.1371/journal.pone.0141641
- Supplemental ubiquinol in patients with advanced congestive heart failure.
Langsjoen PH, Langsjoen AM.
Biofactors. 2008;32(1-4):119-28. PMID: 19096107
- Coenzyme Q10 Regulates Antioxidative Stress and Autophagy in Acute Myocardial Ischemia-Reperfusion Injury.
Liang S, Ping Z, Ge J.
Oxid Med Cell Longev. 2017;2017:9863181. DOI: 10.1155/2017/9863181
Nephrologie
- Amelioration of altered antioxidant enzymes activity and glomerulosclerosis by coenzyme Q10 in alloxan-induced diabetic rats.
Ahmadvand H, Tavafi M, Khosrowbeygi A.
J Diabetes Complications. 2012 Nov-Dec;26(6):476-82. DOI: 10.1016/j.jdiacomp.2012.06.004
- Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress.
Yeung CK, Billings FT 4th, Claessens AJ, Roshanravan B, Linke L, Sundell MB, Ahmad S, Shao B, Shen DD, Ikizler TA, Himmelfarb J.
BMC Nephrol. 2015 Nov 3;16:183. DOI: 10.1186/s12882-015-0178-2
- Mitophagy Plays a Protective Role in Iodinated Contrast-Induced Acute Renal Tubular Epithelial Cells Injury.
Lei R, Zhao F, Tang CY, Luo M, Yang SK, Cheng W, Li XW, Duan SB.
Cell Physiol Biochem. 2018;46(3):975-985. DOI: 10.1159/000488827
- Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease.
Gamboa JL, Billings FT 4th, Bojanowski MT, Gilliam LA, Yu C, Roshanravan B, Roberts LJ 2nd, Himmelfarb J, Ikizler TA, Brown NJ.
Physiol Rep. 2016 May;4(9). DOI: 10.14814/phy2.12780
- La(3+), Gd(3+) and Yb(3+) induced changes in mitochondrial structure, membrane permeability, cytochrome c release and intracellular ROS level.
Liu H, Yuan L, Yang X, Wang K.
Chem Biol Interact. 2003 Jul 25;146(1):27-37. PMID: 12902150
- Update on the renal toxicity of iodinated contrast drugs used in clinical medicine.
Andreucci M, Faga T, Serra R, De Sarro G, Michael A.
Drug Healthc Patient Saf. 2017 May 22;9:25-37 DOI: 10.2147/DHPS.S122207
Neurologie
- Metabolic Dysfunction and Oxidative Stress in Epilepsy.
Pearson-Smith JN, Patel M.
Int J Mol Sci. 2017 Nov 8;18(11). DOI: 10.3390/ijms18112365
- Mitochondria-targeted Antioxidants as a Prospective Therapeutic Strategy for Multiple Sclerosis.
Fetisova E, Chernyak B, Korshunova G, Muntyan M, Skulachev V.
Curr Med Chem. 2017;24(19):2086-2114. DOI: 10.2174/0929867324666170316114452
- Mitochondria in Multiple Sclerosis: Molecular Mechanisms of Pathogenesis.
Patergnani S, Fossati V, Bonora M, Giorgi C, Marchi S, Missiroli S, Rusielewicz T, Wieckowski MR, Pinton P.
Int Rev Cell Mol Biol. 2017; 328:49-103. DOI: 10.1016/bs.ircmb.2016.08.003
- Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species.
Kovac S, Dinkova Kostova AT, Herrmann AM, Melzer N, Meuth SG, Gorji A.
Int J Mol Sci. 2017 Sep 8;18(9). DOI: 10.3390/ijms18091935
- Mitochondrial therapy promotes regeneration of injured hippocampal neurons.
Chien L, Liang MZ, Chang CY, Wang C, Chen L.
Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):3001-3012. DOI: 10.1016/j.bbadis.2018.06.012
- Coenzyme Q10 Influences on the Levels of TNF-α and IL-10 and the Ratio of Bax/Bcl2 in a Menopausal Rat Model Following Lumbar Spinal Cord Injury.
Hassanzadeh S, Jameie SB, Soleimani M, Farhadi M, Kerdari M, Danaei N.
J Mol Neurosci. 2018 Jun;65(2):255-264. DOI: 10.1007/s12031-018-1090-6
- Practice guideline summary: Reducing brain injury following cardiopulmonary resuscitation: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology
Geocadin RG, Wijdicks E, Armstrong MJ, Damian M, Mayer SA, Ornato JP, Rabinstein A, Suarez JI, Torbey MT, Dubinsky RM, Lazarou J
Neurology 2017, 88(22), 2141-2149; https://doi.org/10.1212/WNL.0000000000003966
Onkologie
- Oxidative stress and nerve damage: role in chemotherapy induced peripheral neuropathy.
Areti A, Yerra VG, Naidu V, Kumar A.
Redox Biol. 2014 Jan 18; 2:289-95. DOI: 10.1016/j.redox.2014.01.006
- Dietary supplementation of coenzyme Q10 plus multivitamins to hamper the ROS mediated cisplatin ototoxicity in humans: A pilot study.
Scasso F, Sprio AE, Canobbio L, Scanarotti C, Manini G, Berta GN, Bassi AM.
Heliyon. 2017 Feb 20;3(2):e00251. DOI: 10.1016/j.heliyon.2017.e00251
- Coenzyme Q10 and Oxidative Stress: Inflammation Status in Hepatocellular Carcinoma Patients after Surgery.
Liu HT, Cheng SB, Huang YC, Huang YT, Lin PT.
Nutrients. 2017 Jan 4;9(1). DOI: 10.3390/nu9010029
- Improved survival in patients with end-stage cancer treated with coenzyme Q(10) and other antioxidants: a pilot study.
Hertz N, Lister RE.
J Int Med Res. 2009 Nov-Dec;37(6):1961-71. DOI: 10.1177/147323000903700634
- The effect of coenzyme Q10 on venous ischemia reperfusion injury.
Özalp B, Elbey H, Aydın H, Tekkesin MS, Uzun H.
J Surg Res. 2016 Aug;204(2):304-310. DOI: 10.1016/j.jss.2016.04.075
- Coenzyme Q10 protects skeletal muscle from ischemia-reperfusion through the NF-kappa B pathway.
Boroujeni MB, Khayat ZK, Anbari K, Niapour A, Gholami M, Gharravi AM.
Perfusion. 2017 Jul;32(5):372-377. DOI: 10.1177/0267659116683790
- Integrated mitochondrial function and cancer-related fatigue in men with prostate cancer undergoing radiation therapy.
Hsiao CP, Chen MK, Daly B, Hoppel C.
Cancer Manag Res. 2018 Nov 26;10:6367-6377. DOI: 10.2147/CMAR.S185706
- Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome.
Fukuda S, Nojima J, Kajimoto O, Yamaguti K, Nakatomi Y, Kuratsune H, Watanabe Y.
Biofactors. 2016 Jul 8;42(4):431-40. DOI: 10.1002/biof.1293
Opthalmologie
- Evidence on neuroprotective properties of coenzyme Q10 in the treatment of glaucoma.
Martucci A, Nucci C.
Neural Regen Res. 2019 Feb;14(2):197-200. DOI: 10.4103/1673-5374.244781
- Inhibition of oxidative stress by coenzyme Q10 increases mitochondrial mass and improves bioenergetic function in optic nerve head astrocytes.
Noh YH, Kim KY, Shim MS, Choi SH, Choi S, Ellisman MH, Weinreb RN, Perkins GA, Ju WK.
Cell Death Dis. 2013 Oct 3; DOI: 10.1038/cddis.2013.341
- Mitotropic compounds for the treatment of age-related macular degeneration. The metabolic approach and a pilot study.
Feher J, Papale A, Mannino G, Gualdi L, Balacco Gabrieli C.
Ophthalmologica. 2003 Sep-Oct;217(5):351-7. DOI: 10.1159/000071351
- Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10.
Feher J, Kovacs B, Kovacs I, Schveoller M, Papale A, Balacco Gabrieli C.
Ophthalmologica. 2005 May-Jun;219(3):154-66. DOI: 10.1159/000085248
- Retinal damage caused by high intraocular pressure-induced transient ischemia is prevented by coenzyme Q10 in rat.
Nucci C, Tartaglione R, Cerulli A, Mancino R, Spanò A, Cavaliere F, Rombolà L, Bagetta G, Corasaniti MT, Morrone LA.
Int Rev Neurobiol. 2007;82:397-406. DOI: 10.1016/S0074-7742(07)82022-8
- Consequences of oxidative stress in age-related macular degeneration.
Jarrett SG, Boulton ME.
Mol Aspects Med. 2012 Aug;33(4):399-417. DOI: 10.1016/j.mam.2012.03.009
- Age-Related Macular Degeneration: New Paradigms for Treatment and Management of AMD.
Hernández-Zimbrón LF, Zamora-Alvarado R, Ochoa-De la Paz L, Velez-Montoya R, Zenteno E, Gulias-Cañizo R, Quiroz-Mercado H, Gonzalez-Salinas R.
Oxid Med Cell Longev. 2018 Feb 1;2018:8374647. DOI: 10.1155/2018/8374647
- The Age-Related Eye Disease 2 Study: Micronutrients in the Treatment of Macular Degeneration.
Gorusupudi A, Nelson K, Bernstein PS.
Adv Nutr. 2017 Jan 17;8(1):40-53. DOI: 10.3945/an.116.013177
- Muscle coenzyme Q10 deficiencies in ataxia with oculomotor apraxia 1.
Le Ber I, Dubourg O, Benoist JF, Jardel C, Mochel F, Koenig M, Brice A, Lombès A, Dürr A.
Neurology. 2007 Jan 23;68(4):295-7. DOI: 10.1212/01.wnl.0000252366.10731.43
- Ataxia with oculomotor apraxia type1 (AOA1): novel and recurrent aprataxin mutations, coenzyme Q10 analyses, and clinical findings in Italian patients.
Castellotti B, Mariotti C, Rimoldi M, Fancellu R, Plumari M, Caimi S, Uziel G, Nardocci N, Moroni I, Zorzi G, Pareyson D, Di Bella D, Di Donato S, Taroni F, Gellera C.
Neurogenetics. 2011 Aug;12(3):193-201. DOI: 10.1007/s10048-011-0281-x
Orthopädie
- The role of oxidative and nitrosative stress in the pathology of osteoarthritis: Novel candidate biomarkers for quantification of degenerative changes in the knee joint.
Franz A, Joseph L, Mayer C, Harmsen JF, Schrumpf H, Fröbel J, Ostapczuk MS, Krauspe R, Zilkens C.
Orthop Rev (Pavia). 2018 Jun 14;10(2):7460. DOI: 10.4081/or.2018.7460
- Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice.
Liu T, Ji RR.
Neurosci Bull. 2012 Apr;28(2):145-54. DOI: 10.1007/s12264-012-1207-9
- Lipid peroxidation and antioxidant status in patients with rheumatoid arthritis.
Surapneni KM, Chandrasada Gopan VS.
Indian J Clin Biochem. 2008 Jan;23(1):41-4. DOI: 10.1007/s12291-008-0010-x
- B-vitamin status in relation to bone mineral density in treated celiac disease patients.
Clarke M, Ward M, Dickey W, Hoey L, Molloy AM, Waldron L, Varghese A, McCann A, Blayney JK, McNulty H.
Scand J Gastroenterol. 2015 Aug;50(8):975-84. DOI: 10.3109/00365521.2015.1015603
- Effects of vitamin B12, folate, uric acid, and serum biomarkers of inflammation on bone mineral density in postmenopausal women.
Beyazit F, Pek E.
Prz Menopauzalny. 2018 Jun;17(2):69-76. DOI: 10.5114/pm.2018.77305
- Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint.
Ostalowska A, Birkner E, Wiecha M, Kasperczyk S, Kasperczyk A, Kapolka D, Zon-Giebel A.
Osteoarthritis Cartilage. 2006 Feb;14(2):139-45. DOI: 10.1016/j.joca.2005.08.009
- α-Lipoic acid and superoxide dismutase in the management of chronic neck pain: a prospective randomized study.
Letizia Mauro G, Cataldo P, Barbera G, Sanfilippo A.
Drugs R D. 2014 Mar;14(1):1-7. DOI: 10.1007/s40268-013-0035-3
Psychiatrie
- Mitochondria metabolism and redox mechanisms in psychiatric disorders.
Kim Y, Vadodaria KC, Lenkei Z, Kato T, Gage FH, Marchetto MC, Santos R.
Antioxid Redox Signal. 2018 Dec 26. DOI: 10.1089/ars.2018.7606
- The role of oxidative stress in anxiety disorder: cause or consequence?
Fedoce ADG, Ferreira F, Bota RG, Bonet-Costa V, Sun PY, Davies KJA.
Free Radic Res. 2018 Jul;52(7):737-750. DOI: 10.1080/10715762.2018.1475733
- Redox metabolism abnormalities in autistic children associated with mitochondrial disease.
Frye RE, Delatorre R, Taylor H, Slattery J, Melnyk S, Chowdhury N, James SJ.
Transl Psychiatry. 2013 Jun 18;3:e273. DOI: 10.1038/tp.2013.51
- Mitochondrial Etiology of Neuropsychiatric Disorders.
Pei L, Wallace DC.
Biol Psychiatry. 2018 May 1;83(9):722-730. DOI: 10.1016/j.biopsych.2017.11.018
- Association of mitochondrial DNA 10398 A/G polymorphism with attention deficit and hyperactivity disorder in Korean children.
Hwang IW, Hong JH, Kwon BN, Kim HJ, Lee NR, Lim MH, Kwon HJ, Jin HJ.
Gene. 2017 Sep 30;630:8-12. DOI: 10.1016/j.gene.2017.08.004
- Difference in mitochondrial DNA copy number in peripheral blood cells between probands with autism spectrum disorders and their unaffected siblings.
Yoo HJ, Park M, Kim SA.
World J Biol Psychiatry. 2017 Mar;18(2):151-156. DOI: 10.1080/15622975.2016.1234069
- High levels of mitochondrial DNA are associated with adolescent brain structural hypoconnectivity and increased anxiety but not depression.
Tymofiyeva O, Henje Blom E, Ho TC, Connolly CG, Lindqvist D, Wolkowitz OM, Lin J, LeWinn KZ, Sacchet MD, Han LKM, Yuan JP, Bhandari SP, Xu D, Yang TT.
J Affect Disord. 2018 May;232:283-290. DOI: 10.1016/j.jad.2018.02.024
- Differential mitochondrial DNA copy number in three mood states of bipolar disorder.
Wang D, Li Z, Liu W, Zhou J, Ma X, Tang J, Chen X.
BMC Psychiatry. 2018 May 25;18(1):149. DOI: 10.1186/s12888-018-1717-8
- A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: mitochondrial agents, N-acetylcysteine, and placebo.
Berk M, Turner A, Malhi GS, Ng C, Cotton SM, Dodd S, Samuni Y, Tanious M, McAulay C, Dowling N, Sarris J, Owen L, Waterdrinker A, Smith D, Dean OM.
BMC Med. 2019 Jan 25;17(1):18. DOI: 10.1186/s12916-019-1257-1
- Next Generation Sequencing Mitochondrial DNA Analysis in Autism Spectrum Disorder.
Patowary A, Nesbitt R, Archer M, Bernier R, Brkanac Z.
Autism Res. 2017 Aug;10(8):1338-1343. DOI: 10.1002/aur.1792
Pulmonologie
- Mitochondrial Dysfunction in Airway Disease.
Prakash YS, Pabelick CM, Sieck GC.
Chest. 2017 Sep;152(3):618-626. DOI: 10.1016/j.chest.2017.03.020
- Coenzyme Q10 attenuates lung and liver fibrosis via modulation of autophagy in methotrexate treated rat.
Mohamed DI, Khairy E, Tawfek SS, Habib EK, Fetouh MA.
Biomed Pharmacother. 2019 Jan;109:892-901. DOI: 10.1016/j.biopha.2018.10.133
- Effects of coenzyme Q10 administration on pulmonary function and exercise performance in patients with chronic lung diseases.
Fujimoto S, Kurihara N, Hirata K, Takeda T.
Clin Investig. 1993;71(8 Suppl):S162-6. PMID: 8241703
- Effect of an antioxidant-rich multivitamin supplement in cystic fibrosis.
Sagel SD, Sontag MK, Anthony MM, Emmett P, Papas KA.
J Cyst Fibros. 2011 Jan;10(1):31-6. DOI: 10.1016/j.jcf.2010.09.005
- Effects of an Antioxidant-enriched Multivitamin in Cystic Fibrosis. A Randomized, Controlled, Multicenter Clinical Trial.
Sagel SD, Khan U, Jain R, Graff G, Daines CL, Dunitz JM, Borowitz D, Orenstein DM, Abdulhamid I, Noe J, Clancy JP, Slovis B, Rock MJ, McCoy KS, Strausbaugh S, Livingston FR, Papas KA, Shaffer ML.
Am J Respir Crit Care Med. 2018 Sep 1;198(5):639-647. DOI: 10.1164/rccm.201801-0105OC
- Progressive augmentation and ventilatory long-term facilitation are enhanced in sleep apnoea patients and are mitigated by antioxidant administration.
Lee DS, Badr MS, Mateika JH.
J Physiol. 2009 Nov 15;587(Pt 22):5451-67. DOI: 10.1113/jphysiol.2009.178053
- Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease.
Wiegman CH, Michaeloudes C, Haji G, Narang P, Clarke CJ, Russell KE, Bao W, Pavlidis S, Barnes PJ, Kanerva J, Bittner A, Rao N, Murphy MP, Kirkham PA, Chung KF, Adcock IM.
J Allergy Clin Immunol. 2015 Sep;136(3):769-80. DOI: 10.1016/j.jaci.2015.01.046
- Coenzyme Q10 supplementation reduces corticosteroids dosage in patients with bronchial asthma.
Gvozdjáková A, Kucharská J, Bartkovjaková M, Gazdíková K, Gazdík FE.
Biofactors. 2005;25(1-4):235-40. PMID: 16873952
- Coenzyme Q in asthma.
Comhair SA, Grandon D, Khan A, Zhang R, Hazen SL, Erzurum SC.
Am J Respir Crit Care Med. 2015 Jun 1;191(11):1336-8. DOI: 10.1164/rccm.201412-2259LE
Schmerz
- Mitochondrial dysfunction in migraine.
Yorns WR Jr, Hardison HH.
Semin Pediatr Neurol. 2013 Sep;20(3):188-93. DOI: 10.1016/j.spen.2013.09.002
- Riboflavin and migraine: the bridge over troubled mitochondria.
Colombo B, Saraceno L, Comi G.
Neurol Sci. 2014 May;35 Suppl 1:141-4. DOI: 10.1007/s10072-014-1755-z
- A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study.
Guilbot A, Bangratz M, Ait Abdellah S, Lucas C.
BMC Complement Altern Med. 2017 Aug 30;17(1):433. DOI: 10.1186/s12906-017-1933-7
- Effect of coenzyme Q10 on mitochondrial respiratory proteins in trigeminal neuralgia.
Khuankaew C, Apaijai N, Sawaddiruk P, Jaiwongkam T, Kerdphoo S, Pongsiriwet S, Tassaneeyakul W, Chattipakorn N, Chattipakorn SC.
Free Radic Res. 2018 Apr;52(4):415-425. DOI: 10.1080/10715762.2018.1438608
Stammzellen
- Mitochondrial Regulation in Pluripotent Stem Cells
Xiuling Xu, Shunlei Duan, Fei Yi, Alejandro Ocampo, Guang-Hui Liu, and Juan Carlos Izpisua Belmonte
Cell Metabolism Review, Open ArchivePublished: July 11, 2013 DOI:
Zahnmedizin
- Evaluation of glutathione level in gingival crevicular fluid in periodontal health, in chronic periodontitis and after nonsurgical periodontal therapy: A clinicobiochemical study.
Savita AM, Sarun E, Arora S, Krishnan S.
Contemp Clin Dent. 2015 Apr-Jun;6(2):206-10. DOI: 10.4103/0976-237X.156047
- Role of coenzyme Q(10) as an antioxidant and bioenergizer in periodontal diseases.
Prakash S, Sunitha J, Hans M.
Indian J Pharmacol. 2010 Dec;42(6):334-7. DOI: 10.4103/0253-7613.71884
- Effect of topical application of coenzyme Q10 on adult periodontitis.
Hanioka T, Tanaka M, Ojima M, Shizukuishi S, Folkers K.
Mol Aspects Med. 1994;15 Suppl:s241-8. PMID: 7752836
- Effectiveness of CoQ10 Oral Supplements as an Adjunct to Scaling and Root Planing in Improving Periodontal Health.
Manthena S, Rao MV, Penubolu LP, Putcha M, Harsha AV.
J Clin Diagn Res. 2015 Aug;9(8):ZC26-8. DOI: 10.7860/JCDR/2015/13486.6291
- Application of coenzyme Q10 for accelerating soft tissue wound healing after tooth extraction in rats.
Yoneda T, Tomofuji T, Kawabata Y, Ekuni D, Azuma T, Kataoka K, Kunitomo M, Morita M.
Nutrients. 2014 Dec 10;6(12):5756-69. DOI: 10.3390/nu6125756
- Coenzyme Q Protects Against Age-Related Alveolar Bone Loss Associated to n-6 Polyunsaturated Fatty Acid Rich-Diets by Modulating Mitochondrial Mechanisms.
Varela-Lopez A, Bullon P, Battino M, Ramirez-Tortosa MC, Ochoa JJ, Cordero MD, Ramirez-Tortosa CL, Rubini C, Zizzi A, Quiles JL. J Gerontol A Biol Sci Med Sci. 2016 May;71(5):593-600.
J Gerontol A Biol Sci Med Sci. 2016 May;71(5):593-600. doi: 10.1093/gerona/glv063. Epub 2015 Jul 28. DOI: 10.1093/gerona/glv063
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